Like psychosis, like dementia: Nigella sativa oil enhanced olfactory and amygdalic phenotypes in socially isolated BALB/c mice model of schizophrenia

Abstract Background Social isolation rearing (SIR) is a developmental schizophrenia model with characteristic behavioral symptoms like anxiety and olfactory deficits influenced by the amygdala bulbs respectively. Psychiatric disorders dementias are often comorbid, neuropsychiatric disturbances constituting inherent component of Alzheimer’s. As long‐term side effects mar available antipsychotics, novel natural psycho‐dementia drugs urgently needed. This study thus investigated Nigella sativa (NS) for its impacts on bulb amygdalic phenotypes in socially isolated BALB/c mice. Method Fifty (50) male mice weaned after 21 days birth were grouped equally into five. CTRL NS reared administered normal saline (1ml/kgbw) SIR‐NS, NS‐SIR SIR post‐isolation, pre‐isolation (through maternal exposure) Respective administrations lasted 10 while social 4 weeks. Amygdalic glutamate, GPX dopamine levels as well histo‐architecture addition to body weights, relative brain weight, temperature, food water consumption. Olfactory acuity was assayed sensitivity discrimination tests elevated plus maze. Statistical analysis carried out using one‐way ANOVA at 95% CI. Result In increased brain‐body weight ratios, glutamate which maternally exposed (NS‐SIR mice) compared untreated but also not bulb. Maternal exposure prevented insensitivity no ameliorative effect open arm exploration time pre‐ or post‐treated animals exhibited better histoarchitecture than mice, evidenced neuronal sizes, densities neuro‐piliary staining. Conclusion modelled partial emotional similar schizophrenics. showed significant prophylactic potentials against these especially olfaction. However, farther distance between recommended results.